Open Google Chrome browser > click on 3-dots Menu icon and select Settings in the drop-down menu. Prevent Chrome from Opening PDF Files in Browser Window Hence, the first step is to prevent Chrome from opening PDF Files in the browser window and the next step is to set Adobe as the default PDF handler on your computer. After the File is downloaded to computer, it will open in Adobe Acrobat only if Adobe Reader is installed on your computer and set as the default PDF Handler, if not it will still open using Microsoft Edge, which is the default PDF viewer in Windows.